Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents
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چکیده
منابع مشابه
Transdermal iontophoretic delivery of timolol maleate
Transdermal iontophoresis would be a promising method for the systemic delivery of water soluble and ionic drugs of relatively high molecular size, including peptides. The objective of the present study was to investigate the effect of biological variable such as guinea pig and human cadaver skin and other variables like drug concentration, current density on the transdermal iontophoretic trans...
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PURPOSE The objective of this study was to investigate the use of iontophoresis, soluble microneedles and their combination for the transdermal delivery of glycopyrrolate. METHODS In vitro permeation was tested using full thickness porcine ear skin mounted onto Franz diffusion cells. Iontophoresis (0.5 mA/cm2) was done for 4 h using Ag/AgCl electrodes. For microneedles, three line array (27 n...
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Skin has become an impressive and idealistic platform for the delivery of drugs compared to other routes. However, the stratum corneum “dead, impermeable barrier devoid of biological activity” to skin had challenged the development of transdermal product, which delivers the drugs directly to the systemic circulation at a controlled rate. Recent literature suggests the old doctrine, which states...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2017
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2017.1367975